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SS-31 directly targets the mitochondrial dysfunction that is a primary mechanism of taxane and platinum-based chemotherapy neurotoxicity
It then binds to intrinsic factor (IF), a glycoprotein secreted by the parietal cells of the gastric mucosa
Shaking creates foam that denatures molecules at the air-liquid boundary
PMC 5178091
These reactions are caused by the abrupt exposure of adaptations that have occurred in the nervous system in response to the chronic presence of the drug
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